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Acyl-CoA Thioesterase 7 is Transcriptionally Activated by Kruppel-Like Factor 13 and Promotes the Progression of Hepatocellular Carcinoma.
Xie X, Chen C, Feng S, Zuo S, Zhao X, Li H. Xie X, et al. J Hepatocell Carcinoma. 2021 Dec 23;8:1623-1641. doi: 10.2147/JHC.S338353. eCollection 2021. J Hepatocell Carcinoma. 2021. PMID: 34993160 Free PMC article.
PURPOSE: Acyl-CoA thioesterase 7(ACOT7) plays an important role in the metabolism of fatty acids. ...CONCLUSION: Acyl-CoA thioesterase 7 is transcriptionally activated by Kruppel-like factor 13 and promotes the progre …
PURPOSE: Acyl-CoA thioesterase 7(ACOT7) plays an important role in the metabolism of fatty acids. ...CONC …
Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCzeta-p53-p21 signaling pathway.
Jung SH, Lee HC, Hwang HJ, Park HA, Moon YA, Kim BC, Lee HM, Kim KP, Kim YN, Lee BL, Lee JC, Ko YG, Park HJ, Lee JS. Jung SH, et al. Cell Death Dis. 2017 May 18;8(5):e2793. doi: 10.1038/cddis.2017.202. Cell Death Dis. 2017. PMID: 28518146 Free PMC article.
Acyl-CoA thioesterase 7 (ACOT7) is a major isoform of the ACOT family that catalyzes hydrolysis of fatty acyl-CoAs to free fatty acids and CoA-SH. ...Furthermore, ACOT7 mRNA levels were higher in lung cancer patient tissues …
Acyl-CoA thioesterase 7 (ACOT7) is a major isoform of the ACOT family that catalyzes hydrolysis of fatty …
Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (C20)-acyl chains in macrophages.
Wall VZ, Barnhart S, Kramer F, Kanter JE, Vivekanandan-Giri A, Pennathur S, Bolego C, Ellis JM, Gijón MA, Wolfgang MJ, Bornfeldt KE. Wall VZ, et al. J Lipid Res. 2017 Jun;58(6):1174-1185. doi: 10.1194/jlr.M076489. Epub 2017 Apr 17. J Lipid Res. 2017. PMID: 28416579 Free PMC article.
Acyl-CoA thioesterase 7 (ACOT7) is an intracellular enzyme that converts acyl-CoAs to FFAs. ...Enzymatic thioesterase activity assays in WT and ACOT7-deficient macrophage lysates indicated that endogenous ACOT7 contri …
Acyl-CoA thioesterase 7 (ACOT7) is an intracellular enzyme that converts acyl-CoAs to FFAs. ...Enz …
Amyloid fibril formation, structure and domain swapping of acyl-coenzyme A thioesterase-7.
Kumar M, Teakel SL, Swarbrick C, Chowdhury IS, Thorn DC, Sunde M, Carver JA, Forwood JK. Kumar M, et al. FEBS J. 2023 Aug;290(16):4057-4073. doi: 10.1111/febs.16795. Epub 2023 Apr 27. FEBS J. 2023. PMID: 37042241
Acyl-coenzyme A thioesterase (Acot) enzymes are involved in a broad range of essential intracellular roles including cell signalling, lipid metabolism, inflammation and the opening of ion channels. ...Acot7 formed fibrils in the presence of its …
Acyl-coenzyme A thioesterase (Acot) enzymes are involved in a broad range of essential intracellular roles inclu …
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).
Sharma RS, Harrison DJ, Kisielewski D, Cassidy DM, McNeilly AD, Gallagher JR, Walsh SV, Honda T, McCrimmon RJ, Dinkova-Kostova AT, Ashford MLJ, Dillon JF, Hayes JD. Sharma RS, et al. Cell Mol Gastroenterol Hepatol. 2017 Dec 13;5(3):367-398. doi: 10.1016/j.jcmgh.2017.11.016. eCollection 2018 Mar. Cell Mol Gastroenterol Hepatol. 2017. PMID: 29552625 Free PMC article.
Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity.
Ellis JM, Wong GW, Wolfgang MJ. Ellis JM, et al. Mol Cell Biol. 2013 May;33(9):1869-82. doi: 10.1128/MCB.01548-12. Epub 2013 Mar 4. Mol Cell Biol. 2013. PMID: 23459938 Free PMC article.
Here we have shown that neurons have abundant expression and activity of the long-chain cytoplasmic acyl coenzyme A (acyl-CoA) thioesterase 7 (ACOT7) to regulate lipid retention and metabolism. Unbiased and targeted metabolo …
Here we have shown that neurons have abundant expression and activity of the long-chain cytoplasmic acyl coenzyme A ( …
Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation.
Forwood JK, Thakur AS, Guncar G, Marfori M, Mouradov D, Meng W, Robinson J, Huber T, Kellie S, Martin JL, Hume DA, Kobe B. Forwood JK, et al. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10382-7. doi: 10.1073/pnas.0700974104. Epub 2007 Jun 11. Proc Natl Acad Sci U S A. 2007. PMID: 17563367 Free PMC article.
Acyl-CoA thioesterases (Acots) catalyze the hydrolysis of fatty acyl-CoA to free fatty acid and CoA and thereby regulate lipid metabolism and cellular signaling. We present a comprehensive structural and functional characterization of mou …
Acyl-CoA thioesterases (Acots) catalyze the hydrolysis of fatty acyl-CoA to free fatty acid and CoA …
ACOT7 protects epidermal stem cells against lipid peroxidation.
Zhang G, Ma J, Wu Z, Cao G, Liu C, Song R, Sun R, Chen A, Wang Y, Yin S. Zhang G, et al. In Vitro Cell Dev Biol Anim. 2022 Aug;58(7):549-557. doi: 10.1007/s11626-022-00703-9. Epub 2022 Aug 29. In Vitro Cell Dev Biol Anim. 2022. PMID: 36036847 Free PMC article.
By performing proteomics analysis, we found that the expression of Acyl-CoA thioesterase 7 (ACOT7) was positively correlated with the concentration of transferrin. ...Our data suggest that ACOT7 has an effect on protecting ESCs against ir …
By performing proteomics analysis, we found that the expression of Acyl-CoA thioesterase 7 (ACOT7) was po …
ARNTL2 upregulation of ACOT7 promotes NSCLC cell proliferation through inhibition of apoptosis and ferroptosis.
Wang T, Wang K, Zhu X, Chen N. Wang T, et al. BMC Mol Cell Biol. 2023 Mar 31;24(1):14. doi: 10.1186/s12860-022-00450-5. BMC Mol Cell Biol. 2023. PMID: 37003979 Free PMC article.
However, the molecular mechanisms of ARNTL2 in non-small cell lung cancer (NSCLC) cell growth and proliferation remain to be explored. METHODS: The expression of ARNTL2 and acyl-CoA thioesterase 7 (ACOT7) in lung cancer patients was analyzed bas …
However, the molecular mechanisms of ARNTL2 in non-small cell lung cancer (NSCLC) cell growth and proliferation remain to be explored. METHO …
Loss of ACOT7 potentiates seizures and metabolic dysfunction.
Bowman CE, Selen Alpergin ES, Ellis JM, Wolfgang MJ. Bowman CE, et al. Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E941-E951. doi: 10.1152/ajpendo.00537.2018. Epub 2019 Apr 30. Am J Physiol Endocrinol Metab. 2019. PMID: 31039008 Free PMC article.
Neurons uniquely antagonize fatty acid utilization by hydrolyzing the activated form of fatty acids, long chain acyl-CoAs, via the enzyme acyl-CoA thioesterase 7, Acot7. The loss of Acot7 results in increased fatty acid utilization …
Neurons uniquely antagonize fatty acid utilization by hydrolyzing the activated form of fatty acids, long chain acyl-CoAs, via the en …
25 results